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N6-methyladenine

Candidate: concept label1 source documents6 linked claims
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Aliases

6mA

Evidence Snippets

Therefore, the most recently discovered N6-methyladenine, an additional epigenetic mark with regulatory potential, is also described.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1comparative scopesupports2018Source 1DOIPubMed

Newly discovered DNA base modifications are reported in genomes lacking canonical 5-methylcytosine, suggesting independent epigenetic functions.

Quoted textsource-backed
Interestingly, these newly discovered modifications are also found in the genomes which lack canonical 5-mC, signifying their independent epigenetic functions.
Claim 2conceptual modelsupports2018Source 1DOIPubMed

Combinatorial interactions among known modified DNA bases suggest a more complex epigenetic code than previously appreciated.

Quoted textsource-backed
The potential for combinatorial interaction among the known modified DNA bases suggests that epigenetic codon is likely to be substantially more complicated than it is thought today.
Claim 3functional associationsupports2018Source 1DOIPubMed

Modified DNA bases are associated with regulation of cellular and developmental processes, stem cell pluripotency, neuron development, and tumor development in animals.

Quoted textsource-backed
The epigenetic marks are known to be associated with the regulation of several cellular and developmental processes, pluripotency of stem cells, neuron cell development, and tumor development in animals.
Claim 4functional associationsupports2018Source 1DOIPubMed

N6-methyladenine is described as an additional epigenetic mark with regulatory potential.

Quoted textsource-backed
Therefore, the most recently discovered N6-methyladenine, an additional epigenetic mark with regulatory potential, is also described.
Claim 5review scope summarysupports2018Source 1DOIPubMed

DNA base modifications play important roles in epigenetic control of gene expression in animals and plants.

Quoted textsource-backed
Modification of DNA bases plays vital roles in the epigenetic control of gene expression in both animals and plants.
Claim 6scope boundarysupports2018Source 1DOIPubMed

Among DNA bases, only cytosine and adenine modifications are stated as known in this review.

Quoted textsource-backed
Theoretically, each of the DNA bases can be modified; however, modifications of cytosine and adenine only are known so far.