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First-pass extracted concept

Na+-K+-2Cl- cotransporter NKCC1

Candidate: concept label1 source documents4 linked claims
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Evidence Snippets

having a CFTR channel on the apical side and the Na+/K+ ATPase, NKCC1 and a K+ channel on the basolateral side
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1mechanistic summarysupports2006Source 1DOIPubMed

A protein tyrosine kinase acting on focal adhesion kinase sets levels of NKCC activity in killifish opercular epithelium.

Claim 2review summarysupports2006Source 1DOIPubMed

In killifish opercular epithelium, hyperosmotic shrinkage activates NKCC1 through signaling involving PKC, MLCK, p38, OSR1, and SPAK.

Claim 3review summarysupports2006Source 1DOIPubMed

In killifish opercular epithelium, hypotonic cell swelling deactivates NKCC through a protein phosphatase-dependent process.

Claim 4review summarysupports2006Source 1DOIPubMed

Killifish opercular epithelium is described as a Cl-secreting epithelium with apical CFTR and basolateral Na+/K+ ATPase, NKCC1, and a K+ channel.