First-pass extracted concept

Nab2

Candidate: concept label2 source documents12 linked claims

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Evidence Snippets

In the budding yeast, Saccharomyces cerevisiae, the responsible PABP is the evolutionarily conserved CCCH zinc finger protein Nab2 that facilitates the biogenesis of ∼60 adenosine mRNA poly(A) tails.

Evidence 1Source 1DOIprovenance

In the budding yeast Saccharomyces cerevisiae, the responsible PABP is the evolutionarily conserved CCCH zinc finger protein Nab2 that facilitates the biogenesis of ∼60 adenosine mRNA poly(A) tails.

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025PPRDOI

1 evidence snippet 6 linked claims Claim 1 Claim 2 Claim 3

Source 2primary paper2025MEDDOI PubMed

1 evidence snippet 6 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1mechanismsupports2025Source 2DOI PubMed

In budding yeast, Nab2 facilitates formation of approximately 60-adenosine mRNA poly(A) tails.

Claim 2mechanismsupports2025Source 1DOI

Mature poly(A) tail length is determined by kinetic competition between CPAC-mediated tail elongation and Nab2 RNA binding rather than by the Nab2 RNA footprint.

Claim 3mechanismsupports2025Source 2DOI PubMed

Mature poly(A) tail length is determined by kinetic competition between CPAC-mediated tail elongation and Nab2 RNA binding rather than by the Nab2 RNA footprint.

Claim 4mechanismsupports2025Source 1DOI

Nab2 dimerization directs termination of polyadenylation in reconstituted in vitro reactions.

Claim 5mechanismsupports2025Source 2DOI PubMed

Nab2 dimerization directs termination of polyadenylation in reconstituted in vitro reactions.

Claim 6mechanismsupports2025Source 1DOI

Nab2 facilitates formation of approximately 60-adenosine mRNA poly(A) tails in budding yeast.

Claim 7mechanismsupports2025Source 2DOI PubMed

Poly(A) tail length control operates through a kinetic ruler mechanism in which Nab2 concentration quantifies RNA length.

Claim 8mechanismsupports2025Source 1DOI

Poly(A) tail length control operates through a kinetic ruler mechanism in which Nab2 concentration quantifies RNA length.

Claim 9mechanismsupports2025Source 2DOI PubMed

The Nab2 dimer is stable only on poly(A) tails longer than 25 adenosines, which explains avoidance of premature termination.

Claim 10mechanismsupports2025Source 1DOI

The Nab2 dimer is stable only on poly(A) tails longer than 25 adenosines, which helps avoid premature termination of poly(A) synthesis.

Claim 11mechanismsupports2025Source 2DOI PubMed

Variations in Nab2 RNA binding rate can shift poly(A) tail lengths, and in cells these variations are buffered by autoregulation of Nab2 protein concentration.

Claim 12mechanismsupports2025Source 1DOI

Variations in Nab2 RNA-binding rate can shift poly(A) tail lengths, but in cells these effects are buffered by autoregulation of Nab2 protein concentration.