Nanoparticles are mentioned as an example of a novel delivery formulation being developed for CRISPR applications.
First-pass extracted concept
nanoparticles
Candidate: concept label6 source documents13 linked claims
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Aliases
NPs
Extracted Explainers
What the tool is doing
Resources required
What problem it solves
They are presented in the context of efforts to overcome in vivo packaging and delivery efficiency challenges.
The review frames nanoparticles as a way to deliver therapeutic or imaging cargo efficiently and to increase the therapeutic index of chemotherapeutic drugs.
What it does not solve
Evidence Snippets
Therefore, nanoparticles have extensive research and application value in drug delivery systems.
innovative delivery vehicles, including aptamers, peptides, and nanoparticles
This review considers existing modern approaches aimed to overcome both pre-existing natural immunity and immunity obtained after the administration of a gene therapy drug, which include... pharmacological support (immunosuppressive corticosteroids, inhibitors of various branches of the immune response, nanoparticles, IgG-degrading enzymes).
development of novel delivery formulations (e.g., nanoparticles, exosomes)
The aim of this review is to compare synthetic (engineered) and naturally occurring nanoparticles (NPs) and nanostructured materials (NSMs) to identify their nanoscale properties and to define the specific knowledge gaps related to the risk assessment of NPs and NSMs in the environment.
In recent years, there has been an unprecedented expansion in the field of nanomedicine with the development of new nanoparticles for the diagnosis and treatment of cancer.
Supporting Sources
Linked Claims
Nanoparticles have extensive research and application value in antibody drug delivery systems.
Nanotechnology-based modification of drugs can increase delivery efficiency, targeting, and permeability, reduce resistance to antibody therapy, and improve response rate, safety, and effectiveness.
Since 2020, the LYTAC platform has expanded to include multiple lysosome-targeting receptor targeting techniques and delivery vehicles such as aptamers, peptides, and nanoparticles.
Quoted textsource-backed
Since its inception in 2020, the LYTAC platform has consistently progressed, incorporating several Lysosome-targeting receptor (LTR) targeting techniques and innovative delivery vehicles, including aptamers, peptides, and nanoparticles.
Ongoing efforts to address CRISPR challenges include novel delivery formulations such as nanoparticles and exosomes, artificial intelligence-guided experimental design, and miniaturization of Cas proteins.
Quoted textsource-backed
Ongoing efforts to overcome these include the development of novel delivery formulations (e.g., nanoparticles, exosomes), artificial intelligence-guided experimental design, and miniaturization of Cas proteins.
The review identifies capsid modification, codon optimization, empty capsid traps, corticosteroids, immune response inhibitors, nanoparticles, and IgG-degrading enzymes as approaches to overcome pre-existing and post-administration AAV immunity.
The review discusses regulations implemented by different countries to reduce risks associated with nanoparticles and nanostructured materials.
The review compares synthetic and naturally occurring nanoparticles and nanostructured materials to identify nanoscale properties and knowledge gaps relevant to environmental risk assessment.
The review states that nanoparticles and nanostructured materials have toxic effects toward mammalian cells and tissue and discusses types of toxic reactions.
Nanoparticles are discussed as therapeutic agents in photodynamic therapy, gene therapy, and thermal therapy for cancer.
Quoted textsource-backed
how they can function as therapeutic agents in photodynamic, gene, and thermal therapy
Nanoparticles can bind, absorb, and carry small molecule drugs, DNA, RNA, proteins, and probes with high efficiency.
Quoted textsource-backed
Nanoparticles have unique biological properties given their small size and large surface area-to-volume ratio, which allows them to bind, absorb, and carry compounds such as small molecule drugs, DNA, RNA, proteins, and probes with high efficiency.
Tunable nanoparticle size, shape, and surface characteristics are associated with high stability, high carrier capacity, incorporation of hydrophilic and hydrophobic substances, and compatibility with different administration routes.
Quoted textsource-backed
Their tunable size, shape, and surface characteristics also enable them to have high stability, high carrier capacity, the ability to incorporate both hydrophilic and hydrophobic substances and compatibility with different administration routes
Nanoparticles can be used as molecular imaging agents to detect and monitor cancer progression.
Quoted textsource-backed
how nanoparticles can be used as molecular imaging agents to detect and monitor cancer progression
Nanoparticles can function as carriers for chemotherapeutic drugs to increase therapeutic index in cancer treatment.
Quoted textsource-backed
This review article will discuss how nanoparticles are able to function as carriers for chemotherapeutic drugs to increase their therapeutic index