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Near-infrared fluorescent proteins

Candidate: concept label1 source documents5 linked claims
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Aliases

NIR FPs

Extracted Explainers

What the tool is doing

NIR fluorescent proteins are probe outputs engineered from bacterial photoreceptor-related templates. The review frames them as imaging tools for mammalian cells and whole animals.

Source 1DOI

Resources required

Their development depends on suitable source scaffolds such as BphPs, CBCRs, or APCs and on molecular evolution approaches.

Source 1DOI

What problem it solves

They enable fluorescence-based imaging in live cells and in vivo using near-infrared spectral properties.

Source 1DOI

Evidence Snippets

promising molecular templates to design NIR fluorescent proteins (FPs) and biosensors for studies in mammalian cells and whole animals ... overview imaging applications of NIR FPs in live cells and in vivo
Evidence 1Source 1DOIprovenance

Supporting Sources

Linked Claims

Claim 1application scopesupports2017Source 1DOI

Near-infrared fluorescent proteins derived from these bacterial photoreceptor-related templates have imaging applications in live cells and in vivo, including mammalian cells and whole animals.

Claim 2comparative review scopesupports2017Source 1DOI

The review compares phenotypes of current BphP-based near-infrared fluorescent proteins with fluorescent proteins derived from cyanobacteriochromes and allophycocyanins.

Claim 3engineering strategysupports2017Source 1DOI

Molecular evolution approaches are used to develop near-infrared fluorescent proteins and biosensors from bacterial photoreceptor templates.

Claim 4guidance claimsupports2017Source 1DOI

The review provides guidelines for selecting existing near-infrared fluorescent proteins and for engineering new near-infrared fluorescent proteins from novel templates such as cyanobacteriochromes.

Claim 5template suitabilitysupports2017Source 1DOI

Bacterial phytochromes, some cyanobacteriochromes, and allophycocyanins are promising molecular templates for designing near-infrared fluorescent proteins and biosensors.