First-pass extracted concept

Necrosis

Candidate: concept label1 source documents3 linked claims

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Evidence Snippets

This article describes our current knowledge of the role of NF-kappaB in apoptosis and necrosis.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2006OncogeneDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1context dependencesupports2006Source 1DOI PubMed

NF-κB effects on apoptosis and necrosis vary markedly by cellular context and can include sensitization to death-inducing stimuli.

Quoted textsource-backed

its role in apoptosis and necrosis can vary markedly in different cell contexts, and NF-kappaB can sensitize cells to death-inducing stimuli in some instances

Claim 2knowledge progress summarysupports2006Source 1DOI PubMed

By 2006, substantial progress had been made in understanding NF-κB mechanisms in apoptosis and necrosis and in the regulation of its anti- versus proapoptotic activities.

Quoted textsource-backed

There has been substantial progress in understanding NF-kappaB's mode of action in apoptosis and necrosis and the mechanisms that regulate its anti- vs proapoptotic activities.

Claim 3review scope summarysupports2006Source 1DOI PubMed

NF-κB transcription factors are major regulators of programmed cell death, including apoptosis and necrosis.

Quoted textsource-backed

The nuclear factor-kappaB (NF-kappaB) transcription factors have emerged as major regulators of programmed cell death (PCD) whether via apoptosis or necrosis.