These are in turn modulated by the neuromodulatory systems that are comprised by acetylcholine, noradrenaline, dopamine, serotonin, histamine, orexin (hypocretin), and melanin-concentrating hormone (MCH) neurons.
First-pass extracted concept
neuromodulatory systems in sleep-wake regulation
Candidate: concept label1 source documents4 linked claims
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Aliases
acetylcholine, noradrenaline, dopamine, serotonin, histamine, orexin (hypocretin), and melanin-concentrating hormone (MCH) neurons
Evidence Snippets
Supporting Sources
Linked Claims
Neuromodulatory systems influence other neurons through excitatory and inhibitory receptors, producing coordinated differential changes across functionally distinct cell groups.
Neuromodulatory systems involved in sleep-wake regulation include acetylcholine, noradrenaline, dopamine, serotonin, histamine, orexin, and MCH neurons.
The neuromodulatory systems are each relatively homogeneous in discharge profile, with most discharging maximally during waking and paradoxical sleep or during waking.
Major pharmacological agents used to treat wake and sleep disorders act on GABA and neuromodulatory transmission.