It is now accepted that neurons contain and release multiple transmitter substances. However, we still have only limited insight into the regulation and functional effects of this co-transmission.
First-pass extracted concept
neuronal co-transmission
Candidate: concept label1 source documents4 linked claims
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Evidence Snippets
Supporting Sources
Linked Claims
The nervous system's chemical complexity is high because there are 200 or more neurotransmitters and their interacting effects can generate diverse non-linear and novel consequences.
Quoted textsource-backed
Given that there are 200 or more neurotransmitters, the chemical complexity of the nervous system is daunting. This is made more-so by the fact that their interacting effects can generate diverse non-linear and novel consequences.
Neurons can contain and release multiple transmitter substances.
Quoted textsource-backed
It is now accepted that neurons contain and release multiple transmitter substances.
Insight into the regulation and functional effects of co-transmission remains limited.
Quoted textsource-backed
However, we still have only limited insight into the regulation and functional effects of this co-transmission.
Pharmacological manipulation of a transmitter system may fail to mimic its normal role because transmitters can act in parallel with cotransmitters in the native chemical environment.
Quoted textsource-backed
The relatively poor history of pharmacological approaches likely reflects the fact that manipulating a transmitter system will not necessarily mimic its roles within the normal chemical environment of the nervous system (e.g., when it acts in parallel with cotransmitters).