First-pass extracted concept

neuronal NMDA receptors

Candidate: concept label1 source documents4 linked claims

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Aliases

NMDARs, N-methyl-D-aspartate receptors

Extracted Explainers

What the tool is doing

The paper presents neuronal NMDARs as regulators of zebrafish brain vascular development through neurovascular communication.

Source 1DOI PubMed

What problem it solves

This concept helps explain how neural activity is coupled to endothelial tip-cell growth during brain angiogenesis.

Source 1DOI PubMed

Evidence Snippets

NMDARs expressed on neurons regulate brain vascular development via neurovascular communication.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1cellular mechanismsupports2025Source 1DOI PubMed

The vascular defects caused by neuronal NMDA receptor dysfunction are attributed to reduced growth of vascular endothelial tip cells at the leading edge of brain angiogenic sprouts.

Quoted textsource-backed

These defects are attributed to the reduced growth of vascular endothelial tip cells (ETCs) situating at the leading edge of brain angiogenic sprouts.

Claim 2loss of function effectsupports2025Source 1DOI PubMed

Dysfunction of neuronal NMDA receptors impairs formation of the zebrafish brain vasculature and abolishes neural activity-induced enhancement of brain vascular development.

Quoted textsource-backed

Dysfunction of neuronal NMDARs impairs the formation of the zebrafish brain vasculature and abrogates the neural activity-induced enhancement of the brain vascular development.

Claim 3mechanistic rolesupports2025Source 1DOI PubMed

Neuronal NMDA receptors regulate zebrafish brain vascular development via neurovascular communication.

Quoted textsource-backed

Here, we report that NMDARs expressed on neurons regulate brain vascular development via neurovascular communication.

Claim 4molecular mechanismsupports2025Source 1DOI PubMed

Neuronal NMDA receptor dysfunction down-regulates neuronal vascular endothelial growth factor expression and subsequent endothelial tip-cell calcium activity, impairing endothelial tip-cell growth.

Quoted textsource-backed

At the molecular level, NMDAR dysfunction down-regulates neuronal expression of vascular endothelial growth factor and subsequent global Ca2+ activities of ETCs, thereby impairing ETC growth.