First-pass extracted concept

neuronal replacement

Candidate: concept label1 source documents4 linked claims

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Aliases

stem cell-based neuronal replacement

Evidence Snippets

Second, the neuronal replacement and functional integration of grafted cells into the impaired brain circuitry, which will result in optimum long-term structural and functional repair.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2021Frontiers in Cell and Developmental BiologyDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1comparative outcome summarysupports2021Source 1DOI PubMed

Neuronal replacement with functional integration of grafted cells is described as leading to optimum long-term structural and functional repair.

Claim 2integration hypothesis supportsupports2021Source 1DOI PubMed

The review states that in vivo and ex vivo studies support the hypothesis that human somatic cells reprogrammed into neurons can integrate into lesioned human neuronal circuitry.

Claim 3mechanism summarysupports2021Source 1DOI PubMed

The review describes two main proposed mechanisms for recovery after transplantation in stroke models: an early by-stander effect and neuronal replacement with functional integration.

Claim 4translational supportsupports2021Source 1DOI PubMed

Previous clinical trials in Parkinson's disease are described as proof of principle that stem cell-based neuronal replacement could work in humans.