First-pass extracted concept

neurovascular unit

Candidate: concept label2 source documents2 linked claims

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Aliases

NVU

Evidence Snippets

These clots, blood cells but also blood derivatives in the perivascular space, destabilize the blood-brain barrier from the brain parenchyma side, thereby also functionally weakening the neurovascular unit.

Evidence 1Source 1DOI PubMedprovenance

The review centers on translational brain barrier biology across the blood-brain barrier (BBB), blood-CSF barrier, neurovascular unit (NVU), transport biology, tight junctions, development, and imaging.

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1review2019Translational Stroke ResearchDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Source 2review2011Nature reviews. NeuroscienceDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Linked Claims

Claim 1mechanistic summarysupports2019Source 1DOI PubMed

Blood cells and blood derivatives in the perivascular space are proposed to destabilize the blood-brain barrier and weaken the neurovascular unit after IVH/rt-PA-associated clot dissolution.

Claim 2review scopesupports2011Source 2DOI PubMed

This review synthesizes translational research themes in brain barrier biology spanning the blood-brain barrier, blood-cerebrospinal fluid barrier, neurovascular unit, transport biology, tight junctions, development, and imaging.