First-pass extracted concept

Neutrophils as a permissive niche for Leishmania dissemination

Candidate: concept label1 source documents3 linked claims

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Aliases

Trojan horse model

Extracted Explainers

What the tool is doing

The review describes neutrophils not only as killers of pathogens but also as cells that some Leishmania species exploit during invasion. This supports a permissive-host-cell or Trojan-horse style concept.

Source 1DOI PubMed

What problem it solves

This concept helps explain how parasites can turn an early protective immune response into a route for dissemination.

Source 1DOI PubMed

Alternatives

The web research summary notes earlier reviews explicitly discussing neutrophils as Trojan horses for Leishmania and other intracellular microbes.

Source 1DOI PubMed

Evidence Snippets

several microbes including some Leishmania spp. have evolved a variety of mechanisms to escape neutrophil killing using these cells as a basis to better invade the host

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2017Frontiers in ImmunologyDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1review summarysupports2017Source 1DOI PubMed

Leishmania can use neutrophils as a basis to better invade the host.

Quoted textsource-backed

have evolved a variety of mechanisms to escape neutrophil killing using these cells as a basis to better invade the host

Claim 2review summarysupports2017Source 1DOI PubMed

Leishmania mexicana has been described as able to replicate within neutrophils.

Quoted textsource-backed

as recently described for Leishmania mexicana, even replicate within these cells

Claim 3review summarysupports2017Source 1DOI PubMed

Subversion of neutrophil killing functions by Leishmania promotes parasite spreading and converts a protective neutrophil role into a deleterious one.

Quoted textsource-backed

Subversion of neutrophil killing functions by Leishmania is a strategy that allows parasite spreading in the host with a consequent deleterious impact, transforming the primary protective role of neutrophils into a deleterious one.