First-pass extracted concept

NF-κB

Candidate: concept label1 source documents3 linked claims

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Evidence Snippets

excessive ROS also promotes neuroinflammation by activating the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). NF-κB forms inflammasomes, inhibits silent information regulator 2-related enzyme 1 (SIRT1), and induces pro-inflammatory cytokines

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2023AntioxidantsDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1high level conclusionsupports2023Source 1DOI PubMed

The review concludes that intracellular iron homeostasis is vital for maintaining inflammatory homeostasis.

Claim 2mechanistic summarysupports2023Source 1DOI PubMed

Excessive ROS promotes neuroinflammation by activating NF-κB.

Claim 3mechanistic summarysupports2023Source 1DOI PubMed

The review states that NF-κB forms inflammasomes, inhibits SIRT1, and induces pro-inflammatory cytokines including IL-6, TNF-α, and IL-1β.