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NF-κB regulation of programmed cell death

Candidate: concept label1 source documents5 linked claims
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Aliases

NF-kappaB regulation of programmed cell death, NF-κB in apoptosis and necrosis

Evidence Snippets

The nuclear factor-kappaB (NF-kappaB) transcription factors have emerged as major regulators of programmed cell death (PCD) whether via apoptosis or necrosis.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1context dependencesupports2006Source 1DOIPubMed

NF-κB effects on apoptosis and necrosis vary markedly by cellular context and can include sensitization to death-inducing stimuli.

Quoted textsource-backed
its role in apoptosis and necrosis can vary markedly in different cell contexts, and NF-kappaB can sensitize cells to death-inducing stimuli in some instances
Claim 2disease relevancesupports2006Source 1DOIPubMed

Improper regulation of programmed cell death by NF-κB has pathological consequences ranging from neurodegeneration to cancer and may reduce therapy effectiveness.

Quoted textsource-backed
improper regulation of PCD by NF-kappaB can have severe pathologic consequences, ranging from neurodegeneration to cancer, where its activity often precludes effective therapy
Claim 3knowledge progress summarysupports2006Source 1DOIPubMed

By 2006, substantial progress had been made in understanding NF-κB mechanisms in apoptosis and necrosis and in the regulation of its anti- versus proapoptotic activities.

Quoted textsource-backed
There has been substantial progress in understanding NF-kappaB's mode of action in apoptosis and necrosis and the mechanisms that regulate its anti- vs proapoptotic activities.
Claim 4mechanistic summarysupports2006Source 1DOIPubMed

NF-κB generally protects cells by inducing genes encoding antiapoptotic and antioxidizing proteins.

Quoted textsource-backed
Although NF-kappaB generally protects cells by inducing the expression genes encoding antiapoptotic and antioxidizing proteins
Claim 5review scope summarysupports2006Source 1DOIPubMed

NF-κB transcription factors are major regulators of programmed cell death, including apoptosis and necrosis.

Quoted textsource-backed
The nuclear factor-kappaB (NF-kappaB) transcription factors have emerged as major regulators of programmed cell death (PCD) whether via apoptosis or necrosis.