The paper describes NF-κB signaling as a complex signal transduction pathway involved in physiological and pathological processes and as an important driver of osteosarcoma.
First-pass extracted concept
NF-κB signaling pathway
Candidate: concept label5 source documents6 linked claims
Live refresh every 5sNext refresh in 5s
Aliases
NF-κB pathway
Extracted Explainers
What the tool is doing
What problem it solves
What it does not solve
Evidence Snippets
the sepsis-associated cytokine storm can activate key signaling pathways, such as the NF-κB and p38 MAPK pathways
This article summarizes available information on the effects of pentacyclic triterpenoids on the ... NF-κB ... signaling pathways in ovarian cancer cells.
As a highly complex and unique signal transduction pathway, the NF-κB pathway is involved in various physiological and pathological processes.
The present review elucidates the capacity of andrographolide to inhibit signaling pathways, namely the nuclear factor-κB (NF-κB)...
These signaling pathways include nuclear factor-kappa B (NF-κB)...
Supporting Sources
Linked Claims
The sepsis-associated cytokine storm can activate NF-κB and p38 MAPK signaling in vascular smooth muscle cells, promoting a shift from a contractile to a synthetic phenotype.
The NF-κB signaling pathway is an important driver of osteosarcoma.
Abnormal activation of the NF-κB pathway in osteosarcoma promotes cell proliferation, inhibits apoptosis, and enhances migration, invasion, and immune escape.
The article summarizes available information on the effects of pentacyclic triterpenoids on PI3K/AKT/mTOR, MAPK/ERK, NF-κB, JAK/STAT, Notch, HIF-1α, TGF-β, Wnt/β-catenin, Hippo, and Hedgehog signaling pathways in ovarian cancer cells.
Quoted textsource-backed
This article summarizes available information on the effects of pentacyclic triterpenoids on the PI3K/AKT/mTOR, MAPK/ERK, NF-κB, JAK/STAT, Notch, HIF-1α, TGF-β, Wnt/β-catenin, Hippo, and Hedgehog signaling pathways in ovarian cancer cells.
Inhibition of the NF-κB pathway can inhibit or reverse pathological processes associated with osteosarcoma progression.
The review summarizes that several natural compounds modify multiple inflammation-associated signaling pathways, including NF-κB, AP-1, PTKs, MAPKs, Nrf2, PI3K/AKT, and the ubiquitin-proteasome system.
Quoted textsource-backed
Through current study, an attempt is made to outline and highlight a wide variety of inflammation-associated signaling pathways that have been modified by several natural compounds. These signaling pathways include nuclear factor-kappa B (NF-κB), activator protein (AP)-1, protein tyrosine kinases (PTKs), mitogen-activated protein kinases (MAPKs), nuclear factor erythroid 2-related factor 2 (Nrf2) transcription factors, tyrosine phosphatidylinositol 3-kinase (PI3K)/AKT, and the ubiquitin-proteasome system.