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First-pass extracted concept

NF-kappa B transcription factor

Candidate: concept label1 source documents5 linked claims
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Aliases

NF-kappa B

Evidence Snippets

The effect is mediated by the NF-kappa B transcription factor which is potently and rapidly activated by an H2O2 treatment of cells from its inactive cytoplasmic form.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1inhibitionsupports1991Source 1DOIPubMed

N-acetyl-L-cysteine and other thiol compounds block activation of NF-kappa B by cycloheximide, double-stranded RNA, calcium ionophore, TNF-alpha, active phorbol ester, interleukin-1, lipopolysaccharide, and lectin.

Claim 2inhibitionsupports1991Source 1DOIPubMed

N-acetyl-L-cysteine prevents activation of NF-kappa B by H2O2.

Claim 3mechanismsupports1991Source 1DOIPubMed

H2O2-induced HIV-1 expression and replication is mediated by NF-kappa B, which is potently and rapidly activated from an inactive cytoplasmic form by H2O2 treatment.

Claim 4mechanistic hypothesissupports1991Source 1DOIPubMed

Diverse agents thought to activate NF-kappa B by distinct intracellular pathways may act through a common mechanism involving synthesis of reactive oxygen intermediates.

Claim 5mechanistic hypothesissupports1991Source 1DOIPubMed

Reactive oxygen intermediates serve as messengers mediating directly or indirectly the release of I kappa B from NF-kappa B.