First-pass extracted concept

Ninjurin1

Candidate: concept label1 source documents4 linked claims

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Aliases

Nerve injury induced protein 1, Ninj1

Extracted Explainers

What the tool is doing

The review describes Ninjurin1 as a cell-surface protein induced by nerve injury that promotes axonal growth and mediates leukocyte-related cell communication in inflammation and tissue remodeling.

Source 1DOI PubMed

What problem it solves

In the review framing, Ninjurin1 helps explain how leukocytes enter, adhere, activate, and move within inflamed or remodeling tissues.

Source 1DOI PubMed

What it does not solve

The abstract does not establish Ninjurin1 as a ready-to-use engineering tool, and it notes that its vascular and CNS functions remain incompletely understood.

Source 1DOI PubMed

Alternatives

The provided abstract does not name alternative adhesion molecules or substitute targeting strategies.

Source 1DOI PubMed

Evidence Snippets

Nerve injury induced protein 1, Ninj1 (Ninjurin1) is a cell surface protein that is induced by nerve injury and promotes axonal growth in the peripheral nervous system.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2010Molecules and CellsDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1cell interaction summarysupports2010Source 1DOI PubMed

The review states that Ninjurin1 regulates close interaction between leukocytes and vascular endothelial cells in vascular remodeling and inflamed CNS.

Claim 2functional role summarysupports2010Source 1DOI PubMed

The review summarizes evidence that Ninjurin1 mediates cell communication and enhances leukocyte entry, migration, and activity during developmental and inflammatory processes.

Claim 3proteolytic processing summarysupports2010Source 1DOI PubMed

The review states that Ninjurin1 is cleaved by MMPs, resulting in loss of adhesion during tissue remodeling.

Claim 4therapeutic relevance summarysupports2010Source 1DOI PubMed

The review proposes that Ninjurin1 might be a potential therapeutic target for regulating leukocyte adhesion and trafficking in inflammation and leukocyte-mediated diseases including multiple sclerosis, diabetic retinopathy, and neuropathy.