First-pass extracted concept

nitric oxide

Candidate: concept label2 source documents2 linked claims

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Evidence Snippets

Gas therapy, which utilizes the unique properties of gas molecules such as nitric oxide, carbon monoxide, hydrogen, and hydrogen sulfide, is emerging as a promising and innovative strategy to address these challenges.

Evidence 1Source 1DOI PubMedprovenance

NO has emerged as a fundamental signaling device regulating virtually every critical cellular function, as well as a potent mediator of cellular damage in a wide range of conditions.

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1primary paper2026MEDDOI PubMed

1 evidence snippet 0 linked claims

Source 2review2007Physiological ReviewsDOI PubMed

1 evidence snippet 2 linked claims Claim 1 Claim 2

Linked Claims

Claim 1biological role summarysupports2007Source 2DOI PubMed

Nitric oxide is described as a fundamental signaling molecule regulating many critical cellular functions.

Quoted textsource-backed

NO has emerged as a fundamental signaling device regulating virtually every critical cellular function

Claim 2mechanistic pathogenesis summarysupports2007Source 2DOI PubMed

The review states that much cytotoxicity previously attributed to nitric oxide is instead due to peroxynitrite formed by reaction of nitric oxide with superoxide.

Quoted textsource-backed

Recent evidence indicates that most of the cytotoxicity attributed to NO is rather due to peroxynitrite, produced from the diffusion-controlled reaction between NO and another free radical, the superoxide anion.