First-pass extracted concept

norepinephrine-astroglia-purinergic signaling motif

Candidate: concept label1 source documents4 linked claims

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Aliases

NAP motif

Evidence Snippets

The web research summary states that the Science manuscript/PMC record explicitly names the authors' proposed "norepinephrine-astroglia-purinergic signaling motif" / "NAP motif."

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1conclusionsupports2025Source 1DOI PubMed

The study suggests an evolutionarily conserved astroglial purinergic signaling axis contributes to norepinephrine-mediated behavioral and brain state transitions.

Claim 2mechanismsupports2025Source 1DOI PubMed

Astroglial purinergic signaling implements the inhibitory arm of the norepinephrine-driven behavioral state transition motif.

Claim 3mechanismsupports2025Source 1DOI PubMed

During futility-induced behavioral transitions in larval zebrafish, norepinephrine drives fast excitation and delayed inhibition of behavior and circuit activity.

Claim 4mechanismsupports2025Source 1DOI PubMed

In larval zebrafish, norepinephrine triggers astroglial ATP release, extracellular conversion of ATP into adenosine, and behavioral suppression through activation of hindbrain neuronal adenosine receptors.