First-pass extracted concept

Notch pathway

Candidate: concept label1 source documents3 linked claims

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Aliases

Notch, Notch1 pathway

Extracted Explainers

What the tool is doing

The paper uses Notch pathway perturbation and observation as a mechanistic context for interpreting miR-30a regulation in keratinocytes and 3D epidermis.

Source 1DOI PubMed

Evidence Snippets

We demonstrate that chemical inhibition of the Notch1 pathway induced GFP expression in undifferentiated RIFES/miR-30a keratinocyte cells, with fluorescence redistribution in the basal layers of 3D RIFES/miR-30a epidermis. Moreover, overexpressing miR-30a in 3D epidermal models resulted in NOTCH1 downregulation, suggesting a negative feedback loop between miR-30a and Notch.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2026MEDDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1aging hypothesissupports2026Source 1DOI PubMed

Because the Notch pathway was found downregulated in aged epidermis biopsies, the authors propose that Notch downregulation contributes to miR-30a induction during aging.

Claim 2mechanistic effectsupports2026Source 1DOI PubMed

Chemical inhibition of the Notch1 pathway induced GFP expression in undifferentiated RIFES/miR-30a keratinocyte cells and redistributed fluorescence to basal layers in 3D RIFES/miR-30a epidermis.

Claim 3regulatory relationshipsupports2026Source 1DOI PubMed

Overexpressing miR-30a in 3D epidermal models resulted in NOTCH1 downregulation, suggesting a negative feedback loop between miR-30a and Notch.