The second best known interneuron type expresses a number of neuropeptides and enzymes, including neuropeptide Y, somatostatin, and nitric oxide synthase. The NPY/SOM/NOS interneurons have been identified as PLTS cells.
First-pass extracted concept
NPY/SOM/NOS striatal GABAergic interneurons
Candidate: concept label1 source documents3 linked claims
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Aliases
neuropeptide Y/somatostatin/nitric oxide synthase interneurons, PLTS cells
Evidence Snippets
Supporting Sources
Linked Claims
Three distinct striatal GABAergic interneuron subtypes are generally recognized: parvalbumin-expressing, NPY/SOM/NOS-expressing, and calretinin-expressing interneurons.
Quoted textsource-backed
From the anatomical studies, three distinct GABAergic interneuronal subtypes are generally recognized. The best-studied subtype expresses the calcium-binding protein, parvalbumin. The second best known interneuron type expresses a number of neuropeptides and enzymes, including neuropeptide Y, somatostatin, and nitric oxide synthase. The last GABAergic interneuron subtype expresses the calcium binding protein, calretinin.
NPY/SOM/NOS striatal interneurons correspond to PLTS cells with very high input resistance, low-threshold spike, and prolonged plateau potentials in response to intracellular depolarization or excitatory synaptic stimulation.
Quoted textsource-backed
The NPY/SOM/NOS interneurons have been identified as PLTS cells, exhibiting very high input resistances, low threshold spike and prolonged plateau potentials in response to intracellular depolarization or excitatory synaptic stimulation.
The marker sets defining the three classic striatal GABAergic interneuron classes do not overlap or co-localize.
Quoted textsource-backed
There is no overlap or co-localization of these three different sets of markers.