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Nrf2-Keap1 pathway

Candidate: concept label1 source documents3 linked claims
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Aliases

Nrf2-Keap1 axis

Evidence Snippets

Central to the cellular antioxidant defense system is the nuclear factor erythroid 2-related factor 2 (Nrf2)-Kelch-like ECH-associated protein 1 (Keap1) pathway, which mitigates oxidative damage and preserves mitochondrial integrity.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1mechanistic crosstalksupports2025Source 1DOIPubMed

Emerging evidence indicates mechanistic interplay between the Nrf2-Keap1 axis and the NLRP3 inflammasome, with Nrf2 activation suppressing NLRP3-mediated inflammatory signaling.

Quoted textsource-backed
Emerging evidence indicates a mechanistic interplay between the Nrf2-Keap1 axis and the NLRP3 inflammasome, wherein Nrf2 activation not only counteracts oxidative stress but also suppresses NLRP3-mediated inflammatory signaling.
Claim 2mechanistic rolesupports2025Source 1DOIPubMed

The Nrf2-Keap1 pathway mitigates oxidative damage and preserves mitochondrial integrity in the Parkinson's disease context described by the review.

Quoted textsource-backed
Central to the cellular antioxidant defense system is the nuclear factor erythroid 2-related factor 2 (Nrf2)-Kelch-like ECH-associated protein 1 (Keap1) pathway, which mitigates oxidative damage and preserves mitochondrial integrity.
Claim 3pathogenic effectsupports2025Source 1DOIPubMed

Impaired Nrf2 signaling exacerbates NLRP3 inflammasome activation in Parkinson's disease pathogenesis.

Quoted textsource-backed
with emphasis on how impaired Nrf2 signaling exacerbates NLRP3 inflammasome activation