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First-pass extracted concept

nucleotide excision repair

Candidate: concept label2 source documents3 linked claims
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Aliases

NER

Extracted Explainers

What the tool is doing

NER is presented as one of the repair pathways considered for oxidative DNA lesions in mammalian cells.

Source 2DOIPubMed

What problem it solves

It is included as part of the cellular response to oxidative DNA damage discussed in the review.

Source 2DOIPubMed

What it does not solve

The abstract does not specify which lesion classes are preferentially repaired by NER.

Source 2DOIPubMed

Alternatives

BER is the other explicitly named repair pathway in the abstract.

Source 2DOIPubMed

Evidence Snippets

The nucleotide excision repair (NER) system is a fundamental cellular stress response...
Evidence 1Source 1DOIPubMedprovenance
This review will focus on DNA repair of oxidative lesions by base excision repair (BER) and nucleotide excision repair (NER).
Evidence 2Source 2DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1mechanistic summarysupports2011Source 1DOIPubMed

NER detects a wide diversity of bulky DNA lesions using a small set of DNA binding factors in the XP pathway.

Quoted textsource-backed
The nucleotide excision repair (NER) system is a fundamental cellular stress response that uses only a handful of DNA binding factors... to detect an astounding diversity of bulky base lesions
Claim 2review scope statementsupports1997Source 2DOIPubMed

Reactive oxygen species generated as by-products of cellular metabolism induce multiple forms of DNA damage including base modifications, abasic sites, deoxyribose damage, and single- and double-strand breaks.

Quoted textsource-backed
Reactive oxygen species (ROS) are generated in cells as a by-product of cellular metabolism. ROS react with proteins, lipids, and DNA. DNA base modifications, abasic sites, deoxyribose damage, and single and double strand breaks are all induced following various forms of oxidative stress.
Claim 3review scope statementsupports1997Source 2DOIPubMed

The review focuses on repair of oxidative DNA lesions in mammalian cells by BER and NER, including nuclear and mitochondrial DNA contexts.

Quoted textsource-backed
This review will focus on DNA repair of oxidative lesions by base excision repair (BER) and nucleotide excision repair (NER).