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Off-transient alpha retinal ganglion cell

Candidate: concept label1 source documents5 linked claims
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Aliases

Off-transient αRGC

Evidence Snippets

In the mouse, three αRGC types have been described based on responses to light steps: On-sustained, Off-sustained, and Off-transient.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1cell type classificationsupports2017Source 1DOIPubMed

This study identifies a fourth mouse alpha retinal ganglion cell type with On-transient responses in addition to the three previously described alpha RGC types.

Quoted textsource-backed
In the mouse, three αRGC types have been described based on responses to light steps: On-sustained, Off-sustained, and Off-transient. Here we employed a transgenic mouse line that labels αRGCs in the live retina, allowing systematic targeted recordings. We characterize the three known types and identify a fourth, with On-transient responses.
Claim 2electrophysiological propertysupports2017Source 1DOIPubMed

All four alpha retinal ganglion cell types share a distinctive action potential waveform that is faster than that of other retinal ganglion cell types.

Quoted textsource-backed
They also share a distinctive waveform of the action potential, faster than that of other RGC types.
Claim 3molecular signaturesupports2017Source 1DOIPubMed

Each of the four alpha retinal ganglion cell types has a distinct molecular signature.

Quoted textsource-backed
Molecularly, each type has a distinct signature.
Claim 4shared functional propertysupports2017Source 1DOIPubMed

All four alpha retinal ganglion cell types share a large receptive field center, a weak antagonistic surround, and absence of direction selectivity.

Quoted textsource-backed
All four αRGC types share basic aspects of visual signaling, including a large receptive field center, a weak antagonistic surround, and absence of any direction selectivity.
Claim 5structure function relationshipsupports2017Source 1DOIPubMed

The four alpha retinal ganglion cell types differ morphologically in dendritic stratification level within the IPL, and this accounts for their response properties.

Quoted textsource-backed
Morphologically, they differ in the level of dendritic stratification within the IPL, which accounts for their response properties.