In the mouse, three αRGC types have been described based on responses to light steps: On-sustained, Off-sustained, and Off-transient.
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On-sustained alpha retinal ganglion cell
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On-sustained αRGC
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This study identifies a fourth mouse alpha retinal ganglion cell type with On-transient responses in addition to the three previously described alpha RGC types.
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In the mouse, three αRGC types have been described based on responses to light steps: On-sustained, Off-sustained, and Off-transient. Here we employed a transgenic mouse line that labels αRGCs in the live retina, allowing systematic targeted recordings. We characterize the three known types and identify a fourth, with On-transient responses.
All four alpha retinal ganglion cell types share a distinctive action potential waveform that is faster than that of other retinal ganglion cell types.
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They also share a distinctive waveform of the action potential, faster than that of other RGC types.
Each of the four alpha retinal ganglion cell types has a distinct molecular signature.
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Molecularly, each type has a distinct signature.
All four alpha retinal ganglion cell types share a large receptive field center, a weak antagonistic surround, and absence of direction selectivity.
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All four αRGC types share basic aspects of visual signaling, including a large receptive field center, a weak antagonistic surround, and absence of any direction selectivity.
The four alpha retinal ganglion cell types differ morphologically in dendritic stratification level within the IPL, and this accounts for their response properties.
Quoted textsource-backed
Morphologically, they differ in the level of dendritic stratification within the IPL, which accounts for their response properties.