Opsins are presented as one major class of optical tools used to manipulate neuromodulatory GPCR signaling. The review frames them within optogenetic control of signaling in discrete cell types.
First-pass extracted concept
opsins
Candidate: concept label4 source documents6 linked claims
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Aliases
genetically coded, light-gated ion channels or pumps, light-sensitive proteins
Extracted Explainers
Evidence Snippets
Optogenetics, a revolutionary technique utilizing light-sensitive proteins (opsins) to control the activity of genetically targeted cells
Optogenetics is the use of genetically coded, light-gated ion channels or pumps (opsins) for millisecond resolution control of neural activity.
we summarize four major classes of optical tools to manipulate neuromodulatory GPCR signaling: opsins
In fact, some opsins, including melanopsin, have been identified.
Supporting Sources
Linked Claims
Targeting opsin expression to specific cell types and neuronal pathways can expand understanding of the neural basis of normal and pathological behavior.
Optogenetics uses genetically coded light-gated ion channels or pumps to achieve millisecond-resolution control of neural activity.
These optical techniques targeting specific members of the GPCR signaling pathway provide a broad base for investigating GPCR signaling in behavior and disease states and may support therapeutic development.
Quoted textsource-backed
These emerging techniques targeting specific members of the GPCR signaling pathway offer an expansive base for investigating GPCR signaling in behavior and disease states, in addition to paving a path to potential therapeutic developments.
Optogenetics provides means to control cell signaling with spatiotemporal control in discrete cell types.
Quoted textsource-backed
Optogenetics has revolutionized neuroscience by providing means to control cell signaling with spatiotemporal control in discrete cell types.
The review organizes optical manipulation of neuromodulatory GPCR signaling into four major tool classes: opsins including engineered chimeric receptors, photoactivatable proteins, photopharmacology using caged or photoswitchable molecules, and fluorescent protein-based reporters and biosensors.
Quoted textsource-backed
we summarize four major classes of optical tools to manipulate neuromodulatory GPCR signaling: opsins (including engineered chimeric receptors); photoactivatable proteins; photopharmacology through caging-photoswitchable molecules; fluorescent protein based reporters and biosensors
Opsins, including melanopsin, have been identified in the context of light-sensitive chromatophores discussed by this review.