First-pass extracted concept

optogenetic activation of contralateral prelimbic cortex excitatory neurons

Candidate: concept label1 source documents3 linked claims

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Aliases

optogenetic activation of contralateral PL excitatory neurons

Extracted Explainers

What the tool is doing

This manipulation activates excitatory neurons in the contralateral prelimbic cortex during pain-related experiments. In the abstract, it is used to test whether increasing PL excitatory activity changes pain and anxiety-like behavior.

Source 1DOI PubMed

Resources required

The abstract supports that optogenetic manipulation of contralateral PL excitatory neurons was required. It does not specify the opsin, vector, promoter, hardware, or delivery details.

Source 1DOI PubMed

What problem it solves

It addresses the need for a causal perturbation of PL excitatory neuron activity rather than relying only on correlational observations.

Source 1DOI PubMed

What it does not solve

The abstract does not show that this manipulation identifies the exact downstream circuit or molecular mechanism responsible for the behavioral effects.

Source 1DOI PubMed

Alternatives

The same abstract contrasts this approach with PL lesion, optogenetic inhibition, and Cdk5 knockdown.

Source 1DOI PubMed

Evidence Snippets

Optogenetic activation of contralateral PL excitatory neurons exerts analgesic and anxiolytic effects in mice subjected to chronic pain

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2015Nature CommunicationsDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1functional rolesupports2015Source 1DOI PubMed

Excitatory neurons in the prelimbic cortex regulate pain sensation and anxiety-like behaviors.

Quoted textsource-backed

Here we demonstrate a role for excitatory neurons in the prelimbic cortex (PL), a sub-region of mPFC, in the regulation of pain sensation and anxiety-like behaviours.

Claim 2perturbation effectsupports2015Source 1DOI PubMed

Lesion of the prelimbic cortex contralateral but not ipsilateral to the inflamed paw attenuates hyperalgesia and anxiety-like behaviors in rats with chronic inflammatory pain.

Quoted textsource-backed

Using a chronic inflammatory pain model, we show that lesion of the PL contralateral but not ipsilateral to the inflamed paw attenuates hyperalgesia and anxiety-like behaviours in rats.

Claim 3perturbation effectsupports2015Source 1DOI PubMed

Optogenetic activation of contralateral prelimbic cortex excitatory neurons produces analgesic and anxiolytic effects in mice subjected to chronic pain.

Quoted textsource-backed

Optogenetic activation of contralateral PL excitatory neurons exerts analgesic and anxiolytic effects in mice subjected to chronic pain