Optogenetics ... has emerged as a powerful tool to investigate phase separation in living systems.
First-pass extracted concept
optogenetic control of biomolecular phase separation
Candidate: concept label1 source documents4 linked claims
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optogenetic approaches
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Optogenetic phase-separation tools have been applied in models of amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, and Huntington's disease.
Quoted textsource-backed
We examine how these tools have been applied in models of neurodegenerative diseases, such as amyotrophic lateral sclerosis, Alzheimer's, Parkinson's, and Huntington's disease.
Optogenetic control of phase separation is achieved by fusing disease-associated proteins to light-sensitive oligomerization domains, enabling induction or reversal of condensate formation with spatial and temporal control.
Quoted textsource-backed
This is achieved by fusing disease-associated proteins to light-sensitive oligomerization domains, enabling researchers to induce or reverse condensate formation with precise spatial and temporal control.
Optogenetic approaches provide a framework for elucidating disease mechanisms and informing development of targeted therapies.
Quoted textsource-backed
By enabling precise, dynamic control of protein phase behavior in living systems, optogenetic approaches provide a powerful framework for elucidating disease mechanisms and informing the development of targeted therapies.
Optogenetics has emerged as a powerful tool to investigate biomolecular phase separation in living systems.
Quoted textsource-backed
Optogenetics, originally developed to control neuronal activity with light, has emerged as a powerful tool to investigate phase separation in living systems.