Here we describe the first use of optogenetics to manipulate ion-flux mediated regulation of membrane potential specifically to prevent and cause regression of oncogene-induced tumors.
First-pass extracted concept
optogenetic control of membrane potential in tumorigenesis
Candidate: concept label1 source documents4 linked claims
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Aliases
optogenetic approach to dissect the biophysics of cancer
Evidence Snippets
Supporting Sources
Linked Claims
Injection of mutant-KRAS mRNA induces tumor-like structures with documented similarities to tumors in Xenopus tadpoles.
Quoted textsource-backed
Injection of mutant-KRAS mRNA induces tumor-like structures with many documented similarities to tumors, in Xenopus tadpoles.
This paper reports the first use of optogenetics to manipulate ion-flux-mediated membrane potential regulation to prevent and cause regression of oncogene-induced tumors.
Quoted textsource-backed
Here we describe the first use of optogenetics to manipulate ion-flux mediated regulation of membrane potential specifically to prevent and cause regression of oncogene-induced tumors.
Activation of co-expressed light-activated ion translocators after tumor formation significantly increases the frequency of tumor regression in a process called normalization.
Quoted textsource-backed
activation of co-expressed light-activated ion translocators after tumor formation significantly increases the frequency with which the tumors regress in a process called normalization
The study provides proof-of-principle for interventions that regulate cell state by targeting physiological regulators that can override the presence of mutations.
Quoted textsource-backed
they provide proof-of-principle for a novel class of interventions, directed at regulating cell state by targeting physiological regulators that can over-ride the presence of mutations