Optogenetic methods for functional mapping have been applied in experiments ranging from in vitro investigation of microcircuits, to in vivo probing of inter-regional cortical connections, to examination of global connections within the whole brain.
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optogenetic functional mapping
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Optogenetic stimulation allows arbitrary stimulation of opsin-expressing brain regions, enabling brain mapping independent of behavior or sensory processing.
Optogenetic functional mapping methods have been applied from in vitro microcircuit investigation to in vivo inter-regional cortical probing to whole-brain connection mapping.
Optogenetic tools permit selective manipulation and investigation of neural systems and have enabled mapping of functional connections between stimulated cortical targets and other brain regions.
Challenges remain in finding approaches that permit selective high temporal resolution assessment of stimulated activity in animals that can be followed longitudinally.