Back to first-pass browser

First-pass extracted concept

optogenetic indicators

Candidate: concept label1 source documents6 linked claims
Jump to explainersJump to evidenceJump to sourcesJump to claims
Live refresh every 5sNext refresh in 5s

Extracted Explainers

What the tool is doing

Optogenetic indicators are presented as tools for imaging neural activity in vivo. The abstract places them within a broader effort to record and perturb physiological processes in intact brains.

Source 1DOI

Resources required

The abstract supports a need for in vivo imaging capability in model organisms. It does not provide specific construct, microscope, or delivery requirements.

Source 1DOI

What problem it solves

They address the need for suitable tools to image neural activity in living brains. This is framed as important for neuroscience research.

Source 1DOI

What it does not solve

The abstract does not specify unresolved technical gaps beyond noting that available technologies remain limiting and that current indicator limitations exist.

Source 1DOI

Alternatives

Only generic existing recording technologies are mentioned as the background limitation; no named alternative indicators or modalities are given in the abstract.

Source 1DOI

Evidence Snippets

Neuroscientists are eager to adopt suitable tools for imaging neural activity in vivo, making this a golden age for engineering optogenetic indicators.
Evidence 1Source 1DOIprovenance

Supporting Sources

Linked Claims

Claim 1capability statementsupports2019Source 1DOI

Advances in optogenetics enable optical recording and perturbation of central physiological processes within intact brains of model organisms.

Quoted textsource-backed
Advances in optogenetics now enable optical recording and perturbation of central physiological processes within the intact brains of model organisms.
Claim 2capability statementsupports2019Source 1DOI

Advances in optogenetics enable optical recording and perturbation of central physiological processes within intact brains of model organisms.

Quoted textsource-backed
Advances in optogenetics now enable optical recording and perturbation of central physiological processes within the intact brains of model organisms.
Claim 3coverage statementsupports2019Source 1DOI

Recent sensor advances covered in the source include indicators for calcium, potassium, voltage, and select neurotransmitters, with emphasis on molecular design, properties, and current limitations.

Quoted textsource-backed
We summarize recent advances of sensors for calcium, potassium, voltage, and select neurotransmitters, focusing on their molecular design, properties, and current limitations.
Claim 4forward looking statementsupports2019Source 1DOI

Advances in sensor engineering are expected to yield enduring insights on systems neuroscience.

Quoted textsource-backed
We adopt the view that advances in sensor engineering will yield enduring insights on systems neuroscience.
Claim 5future outlooksupports2019Source 1DOI

Advances in sensor engineering are expected to yield enduring insights on systems neuroscience.

Quoted textsource-backed
We adopt the view that advances in sensor engineering will yield enduring insights on systems neuroscience.
Claim 6technology needsupports2019Source 1DOI

Available technologies limit investigation of the brain because recording biological processes in vivo with suitable spatiotemporal resolution remains challenging.

Quoted textsource-backed
Our ability to investigate the brain is limited by available technologies that can record biological processes in vivo with suitable spatiotemporal resolution.