First-pass extracted concept

optogenetic ion channel effectors for vision restoration

Candidate: concept label1 source documents5 linked claims

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Evidence Snippets

There are two major kinds of optogenetic effectors employed in vision restoration: ion channels and G-protein coupled receptors (GPCRs).

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2018Frontiers in Cellular NeuroscienceDOI PubMed

1 evidence snippet 5 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1design objectivesupports2018Source 1DOI PubMed

New optogenetic tools for vision restoration are being developed to better match the broad spectral sensitivity, light sensitivity, and high temporal sensitivity of human vision.

Claim 2engineering strategysupports2018Source 1DOI PubMed

Work on ion channel based optogenetic therapies has aimed to expand and red-shift their excitation spectra.

Claim 3performance tradeoffsupports2018Source 1DOI PubMed

Light-activatable GPCRs are more light sensitive than ion channel optogenetic effectors but have slower activation and inactivation kinetics.

Claim 4safety limitationsupports2018Source 1DOI PubMed

Ion channel based optogenetic therapies require high intensity light, which can be unsafe at lower wavelengths.

Claim 5therapeutic applicationsupports2018Source 1DOI PubMed

Optogenetic tools can be used therapeutically to restore vision.