First-pass extracted concept

optogenetic reactivation of dormant cone photoreceptors

Candidate: concept label1 source documents4 linked claims

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Evidence Snippets

In degenerated retinas, dormant cones whose cell bodies are intact but no longer respond to light can be optogenetically reactivated.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2026MEDDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1application resultsupports2026Source 1DOI PubMed

Transplantation of optogenetically modified photoreceptors shows functional integration into the retina.

Quoted textsource-backed

The transplantation of optogenetically modified photoreceptors also shows functional integration into the retina.

Claim 2capabilitysupports2026Source 1DOI PubMed

Dormant cones in degenerated retinas can be optogenetically reactivated, restoring cone-dependent signalling pathways.

Quoted textsource-backed

In degenerated retinas, dormant cones whose cell bodies are intact but no longer respond to light can be optogenetically reactivated. This restores all cone-dependent signalling pathways.

Claim 3limitationsupports2026Source 1DOI PubMed

Translation from mouse to human models requires further optimization to maximize therapeutic efficiency.

Quoted textsource-backed

The translation from mouse to human models, however, requires further optimization to maximize the therapeutic efficiency.

Claim 4phenotypic effectsupports2026Source 1DOI PubMed

Optogenetic reactivation in RP mouse models was accompanied by improvements in behavioral tests.

Quoted textsource-backed

This was accompanied by improvements in behavioral tests.