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optogenetic tools for Ca2+ signaling control

Candidate: concept label1 source documents6 linked claims
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Here, we review the various optogenetic tools that have been used to achieve precise control over different Ca2+-permeable ion channels and receptors and associated downstream signaling cascades.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1application scopesupports2021Source 1DOIPubMed

Optogenetic tools have been used to manipulate many Ca2+-dependent biological processes in vitro and in vivo.

Quoted textsource-backed
In addition, we summarize the successes of optogenetics in manipulating many Ca2+-dependent biological processes both in vitro and in vivo.
Claim 2knowledge advancesupports2021Source 1DOIPubMed

Optogenetics has significantly advanced understanding of Ca2+ signaling proteins.

Quoted textsource-backed
In summary, optogenetics has significantly advanced our understanding of Ca2+ signaling proteins
Claim 3limitation of conventional methodssupports2021Source 1DOIPubMed

Conventional techniques for studying Ca2+ signaling have limited spatiotemporal resolution and lack reversibility, which hinders detailed structure-function analysis of ion channels.

Quoted textsource-backed
To date various conventional techniques have provided valuable insights into the roles of Ca2+ signaling. However, their limited spatiotemporal resolution and lack of reversibility pose significant obstacles in the detailed understanding of the structure-function relationship of ion channels.
Claim 4optogenetic advantagesupports2021Source 1DOIPubMed

Optogenetics can partially overcome limitations of conventional Ca2+ signaling methods by enabling remote and well-defined manipulation of Ca2+ signaling.

Quoted textsource-backed
These drawbacks could be partially overcome by the use of optogenetics, which allows for the remote and well-defined manipulation of Ca2+-signaling.
Claim 5review scope statementsupports2021Source 1DOIPubMed

The review covers optogenetic tools for precise control of Ca2+-permeable ion channels, receptors, and associated downstream signaling cascades.

Quoted textsource-backed
Here, we review the various optogenetic tools that have been used to achieve precise control over different Ca2+-permeable ion channels and receptors and associated downstream signaling cascades.
Claim 6translational potentialsupports2021Source 1DOIPubMed

The optogenetic tools reviewed provide an essential basis for potential future therapeutic application.

Quoted textsource-backed
the used tools provide an essential basis for potential future therapeutic application.