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ORAI2

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Aliases

calcium release-activated calcium modulator 2

Evidence Snippets

Here, we report that calcium release-activated calcium modulator 2 (ORAI2), a poorly characterized store-operated calcium (SOC) channel subunit, predominantly upregulated in the lymph node metastasis of gastric cancer, supports cell proliferation and migration.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1clinical correlationsupports2020Source 1DOIPubMed

A high frequency of ORAI2-positive cells in gastric cancer tissues significantly correlates with poor differentiation, invasion, lymph node metastasis, and worse prognosis.

Quoted textsource-backed
Clinical data reveal that a high frequency of ORAI2-positive cells in gastric cancer tissues significantly correlated with poor differentiation, invasion, lymph node metastasis, and worse prognosis.
Claim 2expression associationsupports2020Source 1DOIPubMed

ORAI2 is predominantly upregulated in lymph node metastasis of gastric cancer.

Quoted textsource-backed
ORAI2, a poorly characterized store-operated calcium (SOC) channel subunit, predominantly upregulated in the lymph node metastasis of gastric cancer
Claim 3functional effectsupports2020Source 1DOIPubMed

Gain- and loss-of-function experiments show that ORAI2 promotes cell motility, tumor formation, and metastasis in gastric cancer cell lines and mice.

Quoted textsource-backed
Gain- and loss-of-function showed that ORAI2 promotes cell motility, tumor formation, and metastasis in both gastric cancer cell lines and mice.
Claim 4mechanistic linksupports2020Source 1DOIPubMed

ORAI2 enhances metastatic ability of gastric cancer cells by inducing FAK-mediated MAPK/ERK activation and promoting focal adhesion disassembly at the rear edge of the cell.

Quoted textsource-backed
Moreover, ORAI2 enhanced the metastatic ability of gastric cancer cells by inducing FAK-mediated MAPK/ERK activation and promoted focal adhesion disassembly at rear-edge of the cell.
Claim 5mechanistic linksupports2020Source 1DOIPubMed

ORAI2 mediates store-operated calcium activity and regulates tumorigenic properties through activation of PI3K/Akt signaling.

Quoted textsource-backed
Mechanistically, ORAI2 mediated SOC activity and regulated tumorigenic properties through the activation of the PI3K/Akt signaling pathways.