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orexin/hypocretin system

Candidate: concept label2 source documents5 linked claims
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Aliases

hypocretin, hypocretin system, orexin, orexin system

Evidence Snippets

the hypothalamic neuropeptide orexin (hypocretin) is involved in anxiety states and arousal
Evidence 1Source 1DOIPubMedprovenance
The supplied web research summary states that the anchor review is centered on orexin/hypocretin loss, sleepiness, and cataplexy.
Evidence 2Source 2DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1mechanistic pathwaysupports2013Source 1DOIPubMed

Orexin acts upstream of the amygdala via the noradrenergic locus coeruleus to enable threat learning.

Quoted textsource-backed
we show that orexin acts upstream of the amygdala via the noradrenergic locus coeruleus to enable threat (fear) learning
Claim 2mechanistic rolesupports2013Source 1DOIPubMed

The orexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus.

Quoted textsource-backed
Orexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus
Claim 3method usagesupports2013Source 1DOIPubMed

The study used behavioral pharmacology, slice physiology, and optogenetic techniques to investigate orexin-dependent threat learning circuitry.

Quoted textsource-backed
Using a combination of behavioral pharmacology, slice physiology, and optogenetic techniques
Claim 4temporal specificitysupports2013Source 1DOIPubMed

Orexin enables threat learning specifically during the aversive event.

Quoted textsource-backed
to enable threat (fear) learning, specifically during the aversive event
Claim 5mechanistic focussupports2012Source 2DOIPubMed

The review's mechanistic framing centers on orexin/hypocretin loss in relation to sleepiness and cataplexy.