First-pass extracted concept

orexin system

Candidate: concept label1 source documents4 linked claims

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Aliases

hypocretin, orexin

Extracted Explainers

What the tool is doing

The abstract describes the orexin system as important for maintenance of wakefulness and as involved in feeding, emotion, and reward processes.

Source 1DOI PubMed

What problem it solves

In the review context, it helps explain how arousal, energy homeostasis, and motivation are linked.

Source 1DOI PubMed

Evidence Snippets

Orexin deficiency results in narcolepsy in humans, dogs, and rodents, suggesting that the orexin system is particularly important for maintenance of wakefulness.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2013Frontiers in Behavioral NeuroscienceDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1circuit rolesupports2013Source 1DOI PubMed

The link between orexin and the ventral tegmental nucleus serves to motivate goal-directed behavior.

Quoted textsource-backed

The link between orexin and the ventral tegmental nucleus serves to motivate an animal to engage in goal-directed behavior.

Claim 2functional rolesupports2013Source 1DOI PubMed

Orexin deficiency is associated with narcolepsy and supports an important role for the orexin system in maintaining wakefulness.

Quoted textsource-backed

Orexin deficiency results in narcolepsy in humans, dogs, and rodents, suggesting that the orexin system is particularly important for maintenance of wakefulness.

Claim 3mechanistic rolesupports2013Source 1DOI PubMed

Orexin excites waking-active monoaminergic and cholinergic neurons in hypothalamic and brain stem regions to maintain long consolidated waking periods.

Quoted textsource-backed

Orexin excites waking-active monoaminergic and cholinergic neurons in the hypothalamus and brain stem regions to maintain a long, consolidated waking period.

Claim 4phenotype associationsupports2013Source 1DOI PubMed

Orexin deficiency causes abnormalities in energy homeostasis, stress-related behavior, and reward systems.

Quoted textsource-backed

Orexin deficiency causes abnormalities in energy homeostasis, stress-related behavior, and reward systems.