First-pass extracted concept

parvalbumin interneurons as regulators of PFC circuit function

Candidate: concept label1 source documents4 linked claims

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Aliases

fast-spiking parvalbumin GABAergic interneurons, PV interneurons

Evidence Snippets

Growing evidence supports a fundamental role of fast-spiking parvalbumin (PV) GABAergic interneurons in regulating pyramidal neuron activity to drive appropriate behavioral responses.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2018Frontiers in Neural CircuitsDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1disease association summarysupports2018Source 1DOI PubMed

PV interneuron function is described as heavily diminished in the prefrontal cortex in numerous psychiatric diseases including schizophrenia and autism.

Claim 2functional role summarysupports2018Source 1DOI PubMed

PV interneurons are described as powerful regulators of excitation/inhibition balance in the prefrontal cortex.

Claim 3sufficiency hypothesis summarysupports2018Source 1DOI PubMed

The review frames as a key hypothesis that diminishing PV interneuron function is sufficient to generate symptom patterns corresponding to a range of psychiatric diseases.

Claim 4therapeutic platform hypothesisneutral2018Source 1DOI PubMed

The review speculates that PV-interneuron-centered prefrontal circuitry could represent a platform for development of therapeutic interventions in disorders of prefrontal cortex function.