We propose a role for a fundamental encoding mechanism, pattern separation, in the dentate gyrus (DG)-CA3 circuit in resolving interference between ambiguous or uncertain threats and in preserving episodic content of remote aversive memories in hippocampal-cortical networks.
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pattern separation
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Adult-born dentate granule cells are discussed as modulators of pattern separation that influence interference resolution and maintenance of remote aversive memory precision.
Quoted textsource-backed
We invoke cellular-, circuit-, and systems-based mechanisms by which adult-born dentate granule cells (DGCs) modulate pattern separation to influence resolution of interference and maintain precision of remote aversive memories.
Pattern separation in the dentate gyrus-CA3 circuit is proposed to resolve interference between ambiguous or uncertain threats and preserve episodic content of remote aversive memories.
Quoted textsource-backed
We propose a role for a fundamental encoding mechanism, pattern separation, in the dentate gyrus (DG)-CA3 circuit in resolving interference between ambiguous or uncertain threats and in preserving episodic content of remote aversive memories in hippocampal-cortical networks.
The review frames fear generalization in terms of interference resolution between similar memories.
Quoted textsource-backed
Here, we conceptualize generalization of fear in terms of resolution of interference between similar memories.
Stress is presented as a risk factor for PTSD that affects these mechanisms to increase memory interference and decrease memory precision.
Quoted textsource-backed
We discuss evidence for how these mechanisms are affected by stress, a risk factor for PTSD, to increase memory interference and decrease precision.