First-pass extracted concept

PELP1

Candidate: concept label1 source documents5 linked claims

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Aliases

Proline-, glutamic acid-, and leucine-rich protein 1

Evidence Snippets

Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) is a proto-oncogene that serves as a nuclear and cytoplasmic scaffolding protein.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 5 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1disease associationsupports2025Source 1DOI PubMed

PELP1 expression is upregulated in breast, ovarian, endometrial, prostate, and liver cancers.

Claim 2molecular functionsupports2025Source 1DOI PubMed

PELP1 serves as a nuclear and cytoplasmic scaffolding protein.

Claim 3pathway rolesupports2025Source 1DOI PubMed

PELP1 plays a critical role in nuclear receptor signaling, ribosome biogenesis, chromatin modifications, cell cycle progression, non-genomic signaling, and DNA damage response.

Claim 4prognostic associationsupports2025Source 1DOI PubMed

PELP1 serves as a prognostic factor for poor survival in a variety of cancers.

Claim 5therapeutic relevancesupports2025Source 1DOI PubMed

PELP1 structural motifs, scaffolding function, and oncogenic activity make it a potential target for therapeutic approaches in cancer.