First-pass extracted concept

Perfluoroalkylated compounds

Candidate: concept label1 source documents4 linked claims

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Aliases

PFCs

Evidence Snippets

Perfluoroalkylated compounds (PFCs) ... In this review the major findings of the neurotoxicity of the main PFCs and their suggested mechanisms of action are presented.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2012Archives of ToxicologyDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1environmental relevance summarysupports2012Source 1DOI PubMed

Human blood levels of perfluoroalkylated compounds are high compared with other environmental toxicants, raising concern that susceptible groups may experience harmful combined exposures.

Claim 2mechanism summarysupports2012Source 1DOI PubMed

Mechanistic studies summarized in the review indicate that perfluoroalkylated compounds may affect the thyroid system, calcium homeostasis, protein kinase C, synaptic plasticity, and cellular differentiation.

Claim 3review summarysupports2012Source 1DOI PubMed

Perfluoroalkylated compounds may induce neurobehavioral effects, particularly in developmentally exposed animals.

Claim 4review summarymixed2012Source 1DOI PubMed

The reported neurotoxic effects of perfluoroalkylated compounds are subtle and inconclusive and often occur at concentrations where other toxic effects are also expected.