First-pass extracted concept

phosphodiesterases

Candidate: concept label1 source documents4 linked claims

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Aliases

PDEs

Extracted Explainers

What the tool is doing

Phosphodiesterases are described as enzymes that degrade cAMP and/or cGMP, thereby regulating intracellular cyclic nucleotide concentration.

Source 1DOI PubMed

What problem it solves

In the review's framing, they are central regulators of cyclic nucleotide signaling relevant to memory processes.

Source 1DOI PubMed

Evidence Snippets

Next, we discuss the regulation of the intracellular concentration of cyclic nucleotides via phosphodiesterases, the enzymes that degrade cAMP and/or cGMP

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2020Neuroscience & Biobehavioral ReviewsDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1mechanistic summarysupports2020Source 1DOI PubMed

Phosphodiesterases regulate intracellular cyclic nucleotide concentration by degrading cAMP and/or cGMP.

Claim 2review summarysupports2020Source 1DOI PubMed

Altered cyclic nucleotide signaling has been implicated in the pathophysiology of mnemonic dysfunction in several diseases.

Claim 3review summarysupports2020Source 1DOI PubMed

cAMP and cGMP cascades play important roles in neuronal plasticity and memory function.

Claim 4timing summarysupports2020Source 1DOI PubMed

Specific time windows in cyclic nucleotide signaling during neuroplasticity and memory formation are important and may be targetable to improve memory formation.