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photoactivatable proteins

Candidate: concept label2 source documents6 linked claims
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Extracted Explainers

What the tool is doing

Photoactivatable proteins are identified as a major class of optical tools for manipulating neuromodulatory GPCR signaling.

Source 1DOIPubMed

This review uses photoactivatable proteins to mean proteins whose activity can be induced by light rather than merely reporting fluorescence. They are presented as optogenetic actuators for controlling biochemical signals.

Source 2DOIPubMed

What problem it solves

They expand the set of light-responsive approaches available for controlling signaling pathways.

Source 1DOIPubMed

They provide reversible, quantitative, and precise spatiotemporal control over cellular biochemical functions.

Source 2DOIPubMed

Evidence Snippets

four major classes of optical tools to manipulate neuromodulatory GPCR signaling: ... photoactivatable proteins
Evidence 1Source 1DOIPubMedprovenance
To date, a variety of photoactivatable proteins (refers to induction of protein activity in contrast to fluorescence) have been developed based on the understanding of plant and microbial photoreceptors...
Evidence 2Source 2DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1application scopesupports2016Source 1DOIPubMed

These optical techniques targeting specific members of the GPCR signaling pathway provide a broad base for investigating GPCR signaling in behavior and disease states and may support therapeutic development.

Quoted textsource-backed
These emerging techniques targeting specific members of the GPCR signaling pathway offer an expansive base for investigating GPCR signaling in behavior and disease states, in addition to paving a path to potential therapeutic developments.
Claim 2capability summarysupports2016Source 1DOIPubMed

Optogenetics provides means to control cell signaling with spatiotemporal control in discrete cell types.

Quoted textsource-backed
Optogenetics has revolutionized neuroscience by providing means to control cell signaling with spatiotemporal control in discrete cell types.
Claim 3review scope summarysupports2016Source 1DOIPubMed

The review organizes optical manipulation of neuromodulatory GPCR signaling into four major tool classes: opsins including engineered chimeric receptors, photoactivatable proteins, photopharmacology using caged or photoswitchable molecules, and fluorescent protein-based reporters and biosensors.

Quoted textsource-backed
we summarize four major classes of optical tools to manipulate neuromodulatory GPCR signaling: opsins (including engineered chimeric receptors); photoactivatable proteins; photopharmacology through caging-photoswitchable molecules; fluorescent protein based reporters and biosensors
Claim 4capability summarysupports2013Source 2DOIPubMed

The reviewed optogenetic tools offer reversible, quantitative, and precise spatiotemporal control of enzymatic activity, protein-protein interaction, protein translocation, and gene transcription.

Claim 5comparison summarysupports2013Source 2DOIPubMed

The review compares and contrasts different optogenetic methods based on their advantages and limitations.

Claim 6review scope summarysupports2013Source 2DOIPubMed

The review states that photoactivatable proteins derived from plant and microbial photoreceptors have been developed for optogenetic control of biochemical signals.