Photopharmacology uses light to modulate drug activity. In this review, it is framed as a way to toggle small-molecule inhibitor activity between OFF and ON states.
First-pass extracted concept
photopharmacology
Candidate: concept label6 source documents8 linked claims
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Extracted Explainers
What the tool is doing
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It requires small molecules whose activity is light responsive and an irradiation setup appropriate for optical control. The abstract does not specify exact hardware or wavelengths.
The abstract specifically indicates that water solubility is crucial for applying such molecules in this setting.
What problem it solves
What it does not solve
Evidence Snippets
Photopharmacology enables precise spatial and temporal drug control of receptors by light using modified drug molecules incorporating chemical photoswitches, especially azobenzenes.
The field of photopharmacology has developed around the central concept of using light to endow drug action with spatiotemporal precision.
Photopharmacology is devoted to using light to modulate drugs.
Water-solubility is of crucial importance to apply photoswitchable organic molecules in biological systems, like in the rapidly emerging field of photopharmacology.
Photopharmacology is an emerging field that uses light to precisely control drug activity. This strategy promises to improve drug specificity for reducing off-target effects.
We describe the applications scenarios that can be envisioned in clinical practice and then we use those scenarios to explain the necessary properties that the photoresponsive tools used to control biological function should possess, highlighted by examples from medical imaging, drug delivery and photopharmacology.
Supporting Sources
Linked Claims
Photopharmacology enables precise spatial and temporal control of receptor-directed drug action using modified molecules that incorporate chemical photoswitches, especially azobenzenes.
Photopharmacology uses light to modulate drugs and is being applied to selected enzymatic targets.
Poor selectivity is a persistent challenge in drug development programs and can obscure mechanisms and modes of action.
Photopharmacology uses light to endow drug action with spatiotemporal precision.
Water solubility is crucial for applying photoswitchable organic molecules in biological systems, including photopharmacology.
The combination of photopharmacology and PROTACs has recently gained momentum for discovery and development of new therapies.
Quoted textsource-backed
Recently, the combination strategy of photopharmacology and PROTACs has gained tremendous momentum for its use in the discovery and development of new therapies.
Photopharmacology uses light to precisely control drug activity and promises improved specificity with reduced off-target effects.
Quoted textsource-backed
Photopharmacology is an emerging field that uses light to precisely control drug activity. This strategy promises to improve drug specificity for reducing off-target effects.
The review uses medical imaging, drug delivery, and photopharmacology as application scenarios to define desired properties of photoresponsive tools for controlling biological function.
Quoted textsource-backed
we use those scenarios to explain the necessary properties that the photoresponsive tools used to control biological function should possess, highlighted by examples from medical imaging, drug delivery and photopharmacology.