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First-pass extracted concept

PI3KC3-C1

Candidate: concept label1 source documents4 linked claims
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Aliases

class III phosphatidylinositol 3-kinase complex I

Extracted Explainers

What the tool is doing

PI3KC3-C1 is presented as a core lipid kinase complex involved in autophagy initiation. The review discusses structural studies that illuminate regulation of its activities.

Source 1DOIPubMed

What problem it solves

It represents a second major signaling-convergence point for starting autophagy.

Source 1DOIPubMed

What it does not solve

The abstract does not show that PI3KC3-C1 alone accounts for vesicle fusion or all membrane-supply steps.

Source 1DOIPubMed

Alternatives

The abstract treats ULK1 complex as the paired central initiation complex rather than an alternative.

Source 1DOIPubMed

Evidence Snippets

A range of signaling processes converge on two protein complexes to initiate autophagy: the ULK1 (unc51-like autophagy activating kinase 1) protein kinase complex and the PI3KC3-C1 (class III phosphatidylinositol 3-kinase complex I) lipid kinase complex.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1composition or function summarysupports2017Source 1DOIPubMed

A large fraction of the ULK1 and PI3KC3-C1 complexes consists of noncatalytic domains and subunits, and the ULK1 complex has essential noncatalytic activities.

Claim 2evidence summarysupports2017Source 1DOIPubMed

Structural studies have clarified regulation of catalytic and noncatalytic activities in the ULK1 and PI3KC3-C1 complexes during autophagy initiation.

Claim 3mechanistic modelsupports2017Source 1DOIPubMed

Reconstitution and super-resolution imaging studies support an emerging model in which ULK1 and PI3KC3-C1 coordinate nucleation and fusion of Atg9 and COPII vesicles at the start of autophagosome biogenesis.

Claim 4mechanistic summarysupports2017Source 1DOIPubMed

Autophagy initiation is centered on two protein complexes, ULK1 complex and PI3KC3-C1, that integrate convergent signaling inputs.