First-pass extracted concept

Piezo1 mechanosensitive ion channel

Candidate: concept label1 source documents4 linked claims

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Aliases

Piezo1

Evidence Snippets

We investigated the role of Piezo1 in mediating the intracellular calcium response of HEK293T cells in response to pulsed US.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2019MEDDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1comparative performancesupports2019Source 1DOI PubMed

Piezo1-transfected HEK293T cells show significantly higher ultrasound-elicited calcium increase than Piezo1-knockout HEK293T cells.

Claim 2mechanistic rolesupports2019Source 1DOI PubMed

Ultrasound-elicited intracellular calcium response in HEK293T cells depends on the presence of Piezo1.

Claim 3parameter comparisonsupports2019Source 1DOI PubMed

Compared with 200 Hz PRF and 1 ms burst duration, 2 Hz PRF and 100 ms burst duration produces higher calcium response probability, stronger and faster calcium increase, and greater cell displacement.

Claim 4stimulation parameter dependencesupports2019Source 1DOI PubMed

Ultrasound-elicited calcium response depends critically on pulse repetition frequency or burst duration.