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First-pass extracted concept

polysubstance use

Candidate: concept label1 source documents4 linked claims
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Aliases

co-use

Extracted Explainers

What the tool is doing

This review treats polysubstance use as the key framing concept for studying addiction in a more clinically relevant co-use context.

Source 1DOIPubMed

What problem it solves

It addresses the limitation of studying drug use in isolation when many affected individuals have concurrent substance use disorders.

Source 1DOIPubMed

What it does not solve

The abstract does not provide an operational definition that distinguishes all forms of co-use, sequential use, or dependence patterns.

Source 1DOIPubMed

Alternatives

The contrasted approach in the abstract is studying drug use in isolation.

Source 1DOIPubMed

Evidence Snippets

examining these disorders through the lens of co-use is essential for translatability and improved treatment efficacy
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1prevalence summarysupports2020Source 1DOIPubMed

A substantial fraction of individuals diagnosed with a substance use disorder have concurrent alcohol and illicit drug use disorders.

Claim 2risk association summarysupports2020Source 1DOIPubMed

Having a substance use disorder with one substance increases susceptibility to developing dependence on additional substances.

Claim 3scope summarysupports2020Source 1DOIPubMed

The review focuses on behavioral and neural circuitry in the context of co-use with common pairings of alcohol, nicotine, cannabis, and other addictive substances.

Claim 4translational rationalesupports2020Source 1DOIPubMed

Examining substance use disorders through the lens of co-use is important for translatability and improved treatment efficacy.