The preB cell antigen receptor (preBCR) contains the immunoglobulin mu heavy chain (Ig mu) and signals to the preB cell that heavy chain rearrangement has been successful, a process termed heavy chain selection.
First-pass extracted concept
preB cell antigen receptor
Candidate: concept label1 source documents4 linked claims
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Aliases
preBCR
Evidence Snippets
Supporting Sources
Linked Claims
Engagement of BCR and preBCR rapidly activates receptor-proximal tyrosine kinases including Lyn, Blk, Syk, and Btk.
Quoted textsource-backed
Several protein tyrosine kinases are activated rapidly following engagement of the BCR/preBCR complexes, including members of the Src family (Lyn and Blk), the Syk/ZAP70 family (Syk), and the Tec family (Btk).
In mature B cells and preB cells, antigen receptor signaling responses include survival, proliferation, and differentiation.
Quoted textsource-backed
survival, proliferation, and differentiation in mature B and preB cells
Ig alpha and Ig beta link BCR and preBCR complexes to intracellular signal transduction pathways.
Quoted textsource-backed
Both receptor types from a complex with the Ig alpha and Ig beta proteins that link the predominantly extracellular Ig with intracellular signal transduction pathways.
The preBCR signals successful heavy-chain rearrangement to the preB cell in a process termed heavy chain selection.
Quoted textsource-backed
The preB cell antigen receptor (preBCR) contains the immunoglobulin mu heavy chain (Ig mu) and signals to the preB cell that heavy chain rearrangement has been successful, a process termed heavy chain selection.