Back to first-pass browser

First-pass extracted concept

prelimbic cortex

Candidate: concept label2 source documents6 linked claims
Jump to explainersJump to evidenceJump to sourcesJump to claims
Live refresh every 5sNext refresh in 5s

Aliases

PL

Extracted Explainers

What the tool is doing

The prelimbic cortex is described as an mPFC subregion whose activity is reduced in chronic pain conditions.

Source 1DOIPubMed

The review describes prelimbic cortex as a medial prefrontal subdivision biased toward fear expression. It is discussed within a proposed PL/IL division of labor.

Source 2DOIPubMed

What problem it solves

It helps represent the review's subregion-specific model of mPFC dysfunction in chronic pain.

Source 1DOIPubMed

This concept helps structure evidence about which mPFC subregion is associated with expression of conditioned fear.

Source 2DOIPubMed

What it does not solve

The abstract does not provide a concrete therapeutic or engineering approach centered on prelimbic cortex.

Source 1DOIPubMed

The abstract does not establish PL as an engineered construct or reusable method.

Source 2DOIPubMed

Alternatives

The main contrasted subdivision in the abstract is infralimbic cortex, which is described as biased toward fear suppression.

Source 2DOIPubMed

Evidence Snippets

The medial prefrontal cortex... comprises the anterior cingulate cortex, the prelimbic, and the infralimbic cortex... prelimbic, and infralimbic regions show reduced activity.
Evidence 1Source 1DOIPubMedprovenance
A division of labor has been proposed in which the prelimbic (PL) and infralimbic (IL) subdivisions of the medial prefrontal cortex (mPFC) regulate the expression and suppression of fear in rodents, respectively.
Evidence 2Source 2DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1activity state summarysupports2020Source 1DOIPubMed

In chronic pain, anterior cingulate cortex appears hyperactive whereas prelimbic and infralimbic regions show reduced activity.

Quoted textsource-backed
While the anterior cingulate cortex appears hyperactive, prelimbic, and infralimbic regions show reduced activity.
Claim 2anatomical change summarysupports2020Source 1DOIPubMed

Chronic pain conditions are associated with gray matter loss in anterior cingulate, prelimbic, and infralimbic regions of the medial prefrontal cortex.

Quoted textsource-backed
magnetic resonance imaging has revealed gray matter loss in all these areas in chronic pain conditions
Claim 3functional bias summarysupports2015Source 2DOIPubMed

A proposed division of labor assigns prelimbic cortex to fear expression and infralimbic cortex to fear suppression in rodents.

Quoted textsource-backed
Importantly, a division of labor has been proposed in which the prelimbic (PL) and infralimbic (IL) subdivisions of the medial prefrontal cortex (mPFC) regulate the expression and suppression of fear in rodents, respectively.
Claim 4functional covariation summarysupports2015Source 2DOIPubMed

Under some conditions, prelimbic and infralimbic cortex act in concert and show similar neural activity patterns in response to aversive conditioned stimuli and during expression or inhibition of conditioned fear.

Quoted textsource-backed
We propose that under some conditions, the PL and IL act in concert, exhibiting similar patterns of neural activity in response to aversive conditioned stimuli and during the expression or inhibition of conditioned fear.
Claim 5mechanistic hypothesis summarysupports2015Source 2DOIPubMed

Shared synaptic inputs, parallel downstream outputs, or cortico-cortical interactions may explain similar activity patterns between prelimbic and infralimbic cortex.

Quoted textsource-backed
This may stem from common synaptic inputs, parallel downstream outputs, or cortico-cortical interactions.
Claim 6qualified opposition summarysupports2015Source 2DOIPubMed

Despite functional covariation, prelimbic and infralimbic cortex may still code for largely opposing behavioral outcomes, with prelimbic biased toward fear expression and infralimbic toward suppression.

Quoted textsource-backed
Despite this functional covariation, these mPFC subdivisions may still be coding for largely opposing behavioral outcomes, with PL biased towards fear expression and IL towards suppression.