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preproglucagon neurons

Candidate: concept label1 source documents4 linked claims
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Aliases

PPG neurons

Evidence Snippets

Glucagon-like peptide-1 (GLP-1) is produced within the central nervous system (CNS) by preproglucagon (PPG) neurons.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1associationsupports2025Source 1DOIPubMed

PPG neuron activation is strongly associated with stress.

Claim 2physiological sourcesupports2025Source 1DOIPubMed

Preproglucagon neurons in the CNS produce brain-derived GLP-1.

Claim 3receptor agonist relationshipsupports2025Source 1DOIPubMed

Brain-derived GLP-1 rather than gut-released GLP-1 is the physiological agonist for brain GLP-1 receptors.

Claim 4translational potentialsupports2025Source 1DOIPubMed

PPG neurons have potential as drug targets for anti-obesity applications, with associated risks and benefits that require appraisal.